We're trying something different for Bitsy. At the advice of a holistic expert, we started her on organic, non-GMO hemp oil twice daily. We eliminated all other meds (Denamarin, Gabapentin and Tramadol). So far, we're seeing very good results. Bits seems more interested in her surroundings and more active -- she even wants to play ball again, albeit gently. She got her appetite back, too (spare me the munchies jokes; we've already made them all! ) We started with this: https://myomegapet.com/products/hemp However, it costs nearly $40! So I did a bit of looking and found this: https://www.vitacost.com/vitacost-certified-organic-hemp-oil-non-gmo-24-fl-oz-710-ml-1 It's for humans, and as far as I can tell, it's the exact same thing, except you get a whale of a lot more for one-fourth the price. (I suspect it's a case of jacking up the price for dogs because they can get away with it. ) We'll keep you posted on the results.