Hi, I ran across this site while doing some research on Shelties and pleural effusion. My precious sweet Bella has pleural effusion and we can't figure out what's causing it. She's has several ultrasounds, two echocardiograms, multiple X-rays and blood work. All come back normal, no masses, no cancer from fluid cytology (which came back twice as a modified transudate), blood work seems fine. Liver was slightly elevated and proteins on the low side of normal. We've drained her 4 times, average fluid is around 600cc or ml at a time. Today she had surgery to place two pleural ports so we can drain her ourselves. Once drained, she breathes much better. She is still active and playing but her appetite has decreased. I hand feed her so she eats and put her on a low fat diet. She's only 8 and we just can't put her down since she acts normal and we do love her so much. The latest test is for Bartonella but that takes 3 weeks for the results and we did biopsy the pleural tissue and pericardium to definitely rule out cancer. We are stumped and we are at the end financially. Anyone ever deal with this? What was the cause? Treatment and outcome? I will ask about thyroid, PLE, liver, and infection. I just can't think of anything else. Any information would be greatly appreciated. Thank you!