Sorry I just noticed your message !!! Sally has a nose that my vet-also a sheltie owner- says we will watch. Her nose is really dry and flakey and I am constantly putting Surgeons Cream on it. Vet rec. warm compresses daily but I don't always do this. Actually she doesn't have pigment loss. She has white fur around her nose-just checked to make sure !!! Hoping it isn't collie nose that Mikos has. I think it is a pain to treat sometimes. Is he out in the sun a lot ? Praying you get a diagnosis of dry nose...Melinda