Arthritis pain control

Dang, some sobering reading. I do know it can be hard on livers. I'm giving it to Faith as a hospice medicine to hopefully help with her seizures which was researched by Colorado State Vet school. It seems to be helping a bit with her occasional anxiety also.

WHY can't there just be that magic, safe bullet for pain for humans and pets???
 
Sharon,
You might want to look up silymarin a hepato-protective.
From last year: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667129/

Margi, I also am not seeing much benefit with the glucosamin/chondroitin.
I found a 5-in-1 called Dr. Best 5-in-1 from AMZ (https://www.amazon.com/Doctors-Best-Glucosamine-Chondroitin-Hyaluronic/dp/B006UDGRAS?ref_=ast_sto_dp) which has everything one would want.
After a month or two we thought we saw some improvement but not significant. He's still getting it daily, as my wife and I are also taking it. I also got some bulk glucosamine and added another 1000mg and that hasn't help much more either. The thing I like about that product is that although human dose is 5 tablets, its the Type II collagen that studies show as superior to Glucosamine, and Glucosamine + Chondroitan.
1 capsule give 200mg of T2 Collagen, which is far above the 40mg needed to train the immune systems to stop attacking cartilidge and joints.
For Boots the Chondro-Protect is relatively cheap, seems to work noticeably, and comes in a small vial and is a simple pin prick shot between the shoulder blades once a month or 5-6 weeks.

For humans, I swear fish oil does actually work. 8-10 years ago I'd been working from home for a while already and had gone from about 170-180 to 200, then 220 at the worst. Knees and back were giving me a lot more pain and I started taking Trader Joe's fish oil as I figured it was better than normal drug store. Just threw it into the mix of my daily regimen and forgot about it kind of. About a month later I was hurrying up the stairs and realized I wasn't feeling any pain, and I think it had been a little while since I had.
Thats the only change I made food/vitamin-supplement wise, and I kept on it for probably a year or longer before I ran out and just forgot to restock. By then I'd jumped on Keto for the first time and dropped 20# and that was apparently just enough that my joints/back didn't complain.
ConsumerLabs used to be free and had a great fish oil review with actual mercury testing, etc.
Now I can find this one, and the Amazon affordable looks good as its US made from Norwegian fished stock.
Oh yes, dosage. Any Fish Oil product that just mentions x mgs of fish oil is junk.
They should list EPA/DHA seperately per dose. EPA IIRC is for cardio and muscles, DHA is actually what most of our brains are simply chock full of.
I tried to take enough so that my EPA intake was 1000mg or greater, which was usually 3x Trader Joes.
Not safe if one is one blood thinners or at risk for bleeding/stroke, etc. Wouldn't hurt to ask your Dr.
 
I’ve had limited success with CBD oil for certain issues. It gave some of mine diarrhea when I tried it for arthritis pain, but Flurry has been on it for four years for anxiety and boy do I see a difference the few times I’ve run out.

All of my seniors get glucosamine and Sprite has been on it since her hip surgeries at age 2. It’s one of those supplements my holistic vet says you have to start before the problems to really be effective, so mine are on it by age 6.

The one “magic potion” I do use is the Super Snouts green lipped mussel Sharon suggested a few years ago. That one does work for mine on existing pain and I give it to dogs over 10 as a preventative.
 
I started adding collagen peptides powder to my coffee for my thinning out hair. Will look into dog dosage, never thought of it for them.
My guys both get the Super snouts daily since Sharon suggested it I can't remember how long ago now. I started giving it to Benson as well at age 5 in the hopes of prevention of joint degradation.
I wasn't sure what they were really getting buying fish oil or salmon oil, so I decided to just go to the source. Mine get half ounce of sardines a day. Kinda pricey unless you buy off amazon, but its the real deal for omega 3's....

My cbd oil arrived today so tomorrow will be first dose for Fil. (Ann, too bad its not Benny needing it--could use the diarrhea! LOL)
 
Over here it is called Barensa and is hugely popular and has been widely available for about 5yrs.

I know a lot of people with dogs on this and I used it with Tully. I haven't used it for Della as she has MDR1 and as yet it has not been studied in MDR1 dogs (although there shouldn't be any issues).

Because Tully was under the care of an Internal Medicine Specialist we had a lot of discussions before I tried Barensa, and I read every research paper I could get my hands on - human and animal. Tully had 3 doses, and had great results, esp after the second one. However, each one also set off her IBD/CCE and by the third one I had trouble getting her IBD under control so we stopped. On the IBD/CCE FB group several people with severe IBD dogs also found the 3rd dose set off their dog's IBD. I don't regret giving it to her, it kept her mobile and active for almost a year (until her death) so it was worth it for the QoL. I also tried it for my 15yr old cat but made no difference (and she can still have NSAIDs once or twice a week so I couldn't justify the cost).

A few things to keep in mind
- it is probably safer than using NSAIDs and certainly safer than using pain killers, which also can impact on kidney and also liver. It is potentially better on the stomach, which is why I tried it because Tully had IBD and could not take NSAIDs at all
- everyone I know personally who have used for their dogs it are over the moon with the results, it has definitely improved quality of life for many dogs, Results tend to be quite dramatic after a couple of doses. None of these people have had issues with kidneys or any other organs, Tully had KD when she started and it made no difference to her kidneys.
- As mentioned, a few people (incl me) on the IBD group found it set off their dog's IBD after a few doses. This is IBD (not IBS) so we are talking about unhealthy dogs with an auto-immune disease already.
- IMS said that they are finding the efficacy can drop off over a period of time in some dogs, so it is better to save it for older dogs and not as a first line medication for arthritis. First choice in Australia is always a disease-modifying osteoarthritis drug (DMOAD) like pentosan polysulfate or Zydax (in the US you have another, can't recall it offhand), then NSAIDs or other pain relief.
- It is really expensive - but from my experience with Tully, I don't think you need it as frequently as suggested.
- Something I found interesting in the human studies, was that although the monoclonal antibody pain relievers helped a lot for knee and smaller joint pain, there was a study that found it possibly hastened arthritis in largest joints (eg hip) and they are still researching this. That seems to be the reason the drug isn't so widely available for humans yet.
- Keep in mind that studies so far have been in healthy dogs, or dogs with only mild diseases, and as my IMS said, Tully was neither of these. Some issues may arise in old, unwell dogs that have not been foreseen yet. But then these dogs don't have a lot of time on this earth so waiting around for years of results is probably not an option. And for dogs and esp cats there are not a lot of options for pain relief.

Anyway, hope this helps someone.
 
Sharon7 said:
Totally recommend the Super Snouts brand of GLMussels. It has to be cold-pressed to be effective and not all brands are. I take the human version myself.
Click to expand...
When Zulu started limping and was diagnosed with early arthritis in his left hip, I put him on Super Snouts. That was 2 years ago, hasn't limped since then. Highly recommended.
 
Boots had been doing relatively well until about 5 weeks ago when his right front leg became very painful.
FF today, and he's on a rehab plan with laser, heat, TENS and massage.
He's usually good for the day, then it starts returning, so...
I did get some pharma 99.9% DMSO and am applying it diluted to 60-70% to his elbows and it often works very noticeably.
He's getting a puppy cut tomorrow and the feathering is going to have to go so I have better access for the DMSO and TENS.
Vet has suggested we add Amantadine which is an NMDA antagonist which blocks pain receptors, which in chronic conditions are prone to hyper-sensitization and thus increase pain signaling.
This is totally different than the NGF binding of Librella.
It can take 2-3 weeks before there is noticeable affects or its likely not going to work.
Will update.
 
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