I read the published info too. I was using Advantix and switched off in July to natural since it has been so dry in California that all the fleas dried up and blew away. I can definitely see Advantix is a problem. However, I also have a lot of questions on their leveling factors. Did they make any distinction on fat content in food? Was it high fat content + Advantix, Advantix + even low fat content, etc.? I have also dumped the 18% fat stuff for the shelties and gone to a Fromm food that is 12%. I really would like to know more about this study with factors of age, gender, activity, lineage links, and food. However, I am donated my "backup" Advantix to a shelter. Cubby really itched excessively in the area it was applied. I will have some good old Frontline on hand for an emergency but natural whenever I can.