My vet does them sub-q but in the hind legs. Reason being is that they was some research awhile back that there was a higher incidence of tumors developing at shot locations (or something with tumors and shots it was awhile ago they told me this..dr shelli can you comment on this). as they used to do them in the neck but they found that if the tumors form in the neck its harder to treat than the rear legs and if worse comes to worse they can always amputate a rear leg and the dog can be ok...not so much at the neck level. Both my vets so this approach.