Boots has oral melanoma

Ann, so glad you found this potentially helpful.
Aside from the Taurine, you should definately ask your Drs about NAC, N-Acetyl-Cystine for its x-ray/radiation protection that been studied for years.
This is not an official study but a report on a study reported at RSNA 2021 (radiolocigcal society N. America).
In addition there are many other benefits for NAC: https://www.healthline.com/nutrition/nac-benefits#TOC_TITLE_HDR_4
I started taking this before, during and after scheduled x-rays, and now its part of my daily supplements.
Just a few years ago I broke down and started checking Reddit as so many search results would come up with similar/same questions being asked. Honestly, I was surprised at some of the seriously top-flight Phd level discussion and point/counter-point conversations that go on in many of their supplement, nootropic, health sections. Unlike facebook, twitter or instagram social media that is always suspect, most of the good discussion/Q&A's on these Reddit sections mostly seem to be accurate when I do searches on official gov. research from NIH, etc.
However everything, even things like Taurine, L-Theanine, NAC, etc, there are going to be certain situations and conditions that are going to contraindicate their use. And a lot of times the old 'more must be better' mentality can worsen Y that one might not notice as they're only focused on X.

BTW, Google is great, however going to its Advanced Search can weed out a lot of junk or old science.
A lot of people don't seem to know how to do this, so a quick tutorial:
Go to Google.com
Type in - breast cancer supplements
When the page refreshes, hit the Tools icons below the search box, off to the right.
Some boxes below that will appear, and you want to hit the one labeled "Any time"
From there you can select how far back you want Google to start searching from, Hour, Day, Week, Year, or Custom specific date range.
When I find a cite from 1995 or like that sounds promising but really iffy, I can quickly re-do the search for the past year to see if its been proved out, or search the past 3/4/5 years to see if its still being researched or a study will pop up sometime showing that while promising it ended up being a dead-end.

There is also an Advanced tab where you can refine your search more.

As great as the WWW is and has been for expanding access to information, the past 5-6 years have seen its democratization of knowledge expand by a real order of magnitude.
Boot has a local Oncologist appt for June and a backup at Cornell in July because they said they sometimes will bump someone of if its more critical or unique.
While I suspect Cornell would have the superior expertise since there is probably a cadre of old, young, and geniuses amongst them overall, its possible my local Oncologist is a brilliant Dr. who is still keeping up with cutting edge R&D and is their equal or better still.
My point though is that a lot of these experts are getting their round-up of information from quarterly journals, and that can be month/s after they actually completed a study thats available electronically and not yet finished going through the review, acceptance and publishing process.
Its entirely possible I go in to whomever Boots can see first with studies published a week or month ago that the lone Dr, or even most of a team of specialists are just not aware of yet.
I think you and most anyone else can do this without needing to become an oncologist or geneticists, within reason of course. It just takes effort and mental elbow grease.
Learn what you can, because you are your best advocate and there is so much information from different specialties that can impact other specialties its quite possible for you to come across something that can have just that little bit more positive effect.

Sorry for going long, I sometimes feel like I'm one of those militant vegetarians you end up stuck with at a function.
 
So, Boots Melanocytic tumor diagnostic panel came back, and its negative.

Apparently this is the study: https://pubmed.ncbi.nlm.nih.gov/21078882/

93.9% of 49 canine oral amelonotic or poorly melanocytic neoplasms showed positive on this test.

The local Oncologists office will not schedule until more is known, so its gone back for a staining/differentiation test which will be 10-16 days and then should schedule an early-mid June appt.
Talked with my vet, and he was a little miffed that they were seeming to make it hard to get in.
I asked him if he thought it might be better to plan on going to Cornell July 7 as scheduled vs local, he opined that Cornell is world class and thats what he'd do.
So, I'm expecting a week or two before finding out the test has come back with one of the badder ones like osteosarcoma or gingival melanoma (not sure if the panel tested that).

Currently the boy is loving his new diet with ~8-9oz of protein, and finely ground vegetables.
According to a recent study I found comparing quality kibble vs low carb-higher protein and low carb-mod prot-higher fat, while they are all healthy both low carb diets seem to have statistical significance in raising immunological activty with anti-cancer benefits.

I've also pulled the AAFCO vitamin requirements and have been comparing them to the food-based ones my wife and I are taking. While a little more work needs to be done, its looking like almost all the vitamins required are there, which all/mostly meet the minimums and do not exceed the maximums especially for fat soluble ones.
They do not have a couple oddities like Copper and 1-2 others, however one can always either order those few supplements seperately or find a food that includes them.
For minerals I am thinking of taking uncooked chicken bones and beating them with a hammer in a bag and then grinding them in a food processor. Per NIH "optimum Ca:P ratio of 1.2 to 1.4:1" also http://www.retrieverpro.com/dog-healthy-food-calcium/

I'll probably put a post up in the General Health section comparing AAFCO vs the Costco whole-food vitamin showing how they match up. Even if my dog were not sick, I'd probably talk with my vet to get a baseline and add 1/4-1/3 a tablet a day to boost the cheap synthetics in even good dry food.
 
Sounds like you have a good vet and a good plan; I had no idea about how difficult it is to differentiate these oral cancers. Learn something new often on this Forum. I truly hope it comes back with something not awful for Boots. Please let us know. I'm glad he likes his new diet. Probably wonders why he had to get sick to be able to score food like that.... :winkgrin:
 
Boots is currently in Recovery, picking him up in a couple hours.
Since my last post, we were waiting on staining results.
Ended up taking almost a month vs the 10-16 days because it was again unusual and appaprently went through a lot of discussion before a consensus was reached that it was some form of Sarcoma.
Since the only local Oncologist this side of the State had mentioned to my vet that if it was Sarcoma that they didn't really have much to offer, they recommended a Vet. Dentist that my vet knew of who worked on these types of cancers.
So called up and was able to get an appt. for this Friday, and 30 minutes later got a call back with a cancellation which opened up last Friday and went in for the consult.
Took Boots in the back for a visual exam, and then the Dr. came out and discusses with me that while he didn't see anything, he would know more when he did the Wide Beam CT scan. Was a little taken aback a little later when he pulled out a full quote for the CT and surgery!
Little miscommunication, as I thought we'd be doing the CT scan and then making a decision.
His rationale and normal procedure is to do the CT scan, and then contact the Owner to discuss what he's found while the patient is still under. If its really bad, such as require a significant amount of bone/tissue removal then the procedure can either be stopped for palliative/hospice care, or if warranted actual surgery. My fault actually since he normally gets patients who've either been directed to him via Oncologist/Vet referral vs the disjointed way we arrived.
Big thing is his method doesn't require a patient to be put under a second time, with scheduling delays and additional financial charge.
Whats odd is that he is a Diplomat of the American Veterinary Dental College, of which there are only ~100/world.
So he called about 90 min ago and let me know that there was cancer in the bone, and that it had traveled up a bit from the upper jaw, close to the sinus cavity.
While he's gone for the day, and I'm getting a copy of the x-ray, I don't know exactly how much bone he had to remove. However, I think its a moderate amount, and from discussing with him he made it clear that he is not willing to go to the lengths some vets are with removing really large amounts of bone where they sometime go right up to the zygomatic arch near the eye, or such that they have to partially fold the face up. It sounded like he resected some gum where 2 teeth used to be, some bone there and deeper into the jaw. Looking at canine skull anatomy https://us-browse.startpage.com/av/...db7553d7efbe7dfcf649539ed80f6cac9dc391b03e711
I'm thinking its near the buccinator-oral pointer to the upper jaw, where it really isn't that far from the sinus/nostril as that runs horizontally to the gumline.
The bad bone and the good bone margins will be sent to his histo-patholigist who will probably determine better that it actually is, and more importantly check the good bone to see if he got far enough beyond the cancerous area to potentially have removed it all.
Obviously not hanging my hat on this, but an additional 6/8/12 months in the summer after 3 weeks of initial recovery seems likely.
I'm still days later stunned that there is an actual world-class expert in my off the beaten track neck of the woods who's given my guy one of the best chances for extra quality time in our life.

Appreciate everyone's thoughts and insights along the way.

I am putting a post re: CBD and pain relief in the forums that hopefully some might find useful.
 
Thanks, from the x-rays it looks like he took out about a thumb-sized chunk from the first knuckle.
The boy has been up and about today like normal, without any sign that he even had surgery. And this was before he got his meds.
Further checking seems to show that CBD does work well with Gabapentin so added that as well.
Just checked the canine cancer vaccine (https://news.yale.edu/2024/03/05/novel-cancer-vaccine-offers-new-hope-dogs-and-those-who-love-them) and will see if that is a possability.
 
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