ClantyreSheltie
Forums Sage
I have read, (here I think) that some Shelties can have reactions even seizures to Heartgard, I suppose this would be the MDR dogs in some cases.
Any dog can have any reaction to any medication, theoretically. I know of dogs who have had seizures when topicals are applied.
However, we know that the dose of ivermectin in heartguard is well below the problem threshold for MDR-1 dogs. Dr. Shelli has said this over and over.

